Four-strand Crossing-over
نویسندگان
چکیده
منابع مشابه
The synaptinemal complex and four-strand crossing over.
The synaptinemal complex provides a structural basis for four-strand crossing over: prior to chromosome pairing, both sister chromatids of each homologous chromosome participate in the genesis of one lateral component. During precise pairing, the two lateral components are combined into one synaptinemal complex per bivalent.
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ROSSING OVER, the exchange of chromatin between homologous chroC mosomes, is of utmost importance in genetic studies. Although little is known about the mechanism which is responsible for this exchange, a number of facts on this subject have been fairly well established: (1) Crossing over is produced by breakage and reunion of broken end's (even on BELLING'S hypothesis, breakage and reunion hav...
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The problem of whether sister-strand crossing over does or does not occur is of some importance for general theories of crossing over. In most genetic experiments, i t is not possible to decide whether sister-strand exchange has or has not occurred because the results of both alternatives are indistinguishable. But with the use of the closed-X chromosome, described by L. V. MORGAN (1933), a sol...
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DNA double-strand breaks (DSBs) are one of the most deleterious types of lesions to the genome. Synthesis-dependent strand annealing (SDSA) is thought to be a major pathway of DSB repair, but direct tests of this model have only been conducted in budding yeast and Drosophila To better understand this pathway, we developed an SDSA assay for use in human cells. Our results support the hypothesis ...
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ژورنال
عنوان ژورنال: Nature
سال: 1952
ISSN: 0028-0836,1476-4687
DOI: 10.1038/170986a0